BR-HIMF | Mice
At a glance
- Holding mice under PC2 conditions
- Established in 2025, we generate cohorts of preclinical models with immune systems that faithfully replicate humans
- Supporting translational research for Australian resarchers without going abroad
- Our services suit the development and testing of novel therapeutics
- We provide technical serviecs, experimetnal design and consultation, including ethics support.
The Human Immune Model Facility (HIMF), was established to provide humanised preclinical models for Australian research, a capability especially suited to the development and testing of novel therapeutics. Previously only commercially available through the USA or Europe at greater cost and less accessibility, HIMF provides immunodeficient recipient models from The Jackson Laboratory (JAX) that have been transplanted with a human immune system using isolated stem cells.
There is increasing demand globally across academia and industry for innovative preclinical technologies that faithfully recapitulate human immune responses to more reliably and efficiently facilitate informed decision making in preclinical drug development. This facility will enable world class translational research using cutting-edge technology not currently available in the Australian market, along with technical and experimental expertise, support and services to the national research and development community.
Capabilities
- Specialised technical services
- Ideal for testing novel immunotherapies
- Experimental design and consultation, including ethics support
- Generation of cohorts of preclinical models with immune systems that faithfully replicate that of humans
- Suited to preclinical studies in oncology, hematology, immunology, autoimmunity, infectious disease and inflammation.
BR-HIMF Facility metrics
Current users can use the below facility information to report in enough detail facility information. Reporting animal research in adherence with the ARRIVE guidelines ensures transparent and thorough reporting. This enables readers and reviewers to scrutinise the research adequately, evaluate its methodical rigour, and reproduce the methods or findings. Research groups considering non-standard caging (opting out of a standard cage), should consider the following article to support understanding about indirect impacts to research design Reproducibility and Rigor in Animal-Based Research.
To be confirmed for 2025
BR-HIMF Pathogen exclusion list
BR-HIMF Health reports
To be confirmed for 2025
Contact
Translational Model Facilities Manager
Carina Walpole